Detection of Extended Spectrum Beta Lactamases (ESBLs) Producing Enterobacteriaceae Family from Urinary Tract Infection (UTI) Patients

Background: Extended spectrum beta lactamase (ESBLs) are betalactamase capable of conferring bacterial resistance to the first, second and third-generation Cephalosporin’s but these inhibited by inhibitors such as clavulanic acid. The ESBLs typically plasmidmediated enzymes, mostly produced E. coli Klebsiella pneumonia Enterobacteriaceae family. enzymes were discovered in Germany 1983 from pneumonia. ESBL-producing gram negative bacteria have been responsible for numerous outbreaks infection throughout several counties region challenging control issues. Different phenotypic test ESBL detection developed, which easy use cost effective. Materials Methods: In this study, 10 Urine samples collected Government Hospital, Dharmapuri, Tamil Nadu. Collected clinical isolated identified standard microbiological method. antibiotic susceptibility testing was performed disc-diffusion preliminary carried out combination (CDDT) Performed using Kirby- bauer disc diffusion method on muller hinton agar. Results: Totally investigated Among 7 positive Urinary tract (UTI), 20 micro-organisms belonging 3 genus isolated. Of patients, female male. most prevalent species. multidrug-resistant (resistance five or more antibiotics) among isolates. Uro pathogens positive. Conclusion: Based results, predominated samples, giving maximum frequency producing followed (70%) (30%) combined disk Herbal medicine should be perform UTI patients prevent spread more. Only limited therapeutically options ESBL-PE.